THE PKRRATING DIARIES

3B). R526 from the loop involving αJ and αI anchors the C-terminal portion of the activation loop by forming a salt bridge with E458 at the base of αEF. Q459 stabilizes the HRD motif by a hydrogen bond to the key chain carbonyl of R413. The suggestion of the activation phase is stabilized by a hydrogen bond in between Y454 and E480 from αF. dur